Endocrine Abstracts

Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disorders in Western countries, encompassing a spectrum of diseases ranging from simple steatosis to liver fibrosis and cirrhosis. Polycystic Ovary Syndrome (PCOS), the most common endocrine disorder of women during the reproductive period, is often implicated with NAFLD.Aim: To investigate the potential involvement of PCOS on the aggravation of NAFLD by...

Non-alcoholic fatty liver disease NAFLD has been associated with androgen deficiency, yet in the majority of patients with non-alcoholic steatohepatitis NASH, androgens levels are normal. In contrast, women with polycystic ovarian syndrome PCOS, which is characterised by androgen excess, have evidence of increased liver fat. Our hypothesis is that androgen exposure to the liver may be crucial in the amount of lipid that can accumulate in hepatocytes. C3A human hepatoma cells w...

Oxidative stress in humans has been associated with obesity. Puberty is a maturation period characterized mainly by changes of the GH and the gonadotrophin hormones secretion. To investigate the possible association of the GH and the hypothalamic–pituitary–gonadal (HPG) axes before and during early puberty, with the pro- and anti-oxidation mechanisms 76 healthy, pre-pubertal normal weight (n=28), pre-pubertal obese (n=11), early pubertal normal weig...

‘Stress’ is defined as a state of disharmony or threatened homeostasis. Pregnancy is a transient period of relative hypercortisolism. Chronic or acute stressors influence maternal and fetal Hypothalamus-Pituitary-Adrenal Axes (HPA) during pregnancy. Insulin sensitivity is a feature of normal pregnancy, possibly reflecting an adaptive phenomenon aiming at diverting maternal glucose towards fetal needs. We investigated the effect of maternal stress into maternal insuli...

The control of fertility constitutes a global health issue, because overpopulation and unintended pregnancy have both major personal and societal impact. Oral contraceptives (OCs) have been the gold standard for contraception since their introduction in 1960. They are used for both their contraceptive and noncontraceptive benefits. Hormonal contraceptives are made of either oestrogen-progestin combinations or progestins alone. Attempts have been made to use other classes of st...

Background and aim: Low energy availability (LEA) may lead to menstrual disorders and low bone mineral density, predisposing to the female athlete triad (FAT) syndrome. The primary aim of this review was to systematically investigate the impact of sports on the energy status of professional female athletes compared to sedentary, recreationally active controls, with regard to their menstrual status and bone mineral density (BMD). A secondary aim was the estimation of the combin...

Introduction: The presence of antiphospholipid antibodies is associated pathogenically with thrombotic vascular events and resulting pregnancy complications. Studies support that antiphospholipid antibodies (aPL) impair female fertility by interfering with endometrial decidualization and implantation. This meta-analysis aims to determine the prevalence of aPL in women undergoing assisted reproductive techniques (ART) for in Vitro Fertilization and Embryo Transfer (IVF-ET)....

Background and Aim: Over the past years, hybrid closed-loop (HCL) systems have emerged as the state-of-the art treatment of type 1 diabetes (T1D), and there is sufficient evidence to support their safety and value. The aim of this review was to evaluate all the available literature regarding the impact of HCL systems on diabetes management compared to sensor augmented pump (SAP) systems.Methods: An extensive literature search was conducted through electr...

Background: Anabolic androgenic steroids (AAS) are widely used to improve performance and/or enhance appearance. The aim of this study was to assess the impact of AAS on the reproductive system of athletes.Methods: An electronic literature search was conducted, using the databases MEDLINE, CENTRAL, Scopus and Google Scholar. Studies including AAS use in any type, dose, form or duration of intake were included in the review. Main outcomes were AAS effects...

Introduction: Bisphenol A (BPA) is a chemical compound found in a variety of everyday products. Exposure to BPA impacts negatively ovarian response, number of fertilized oocytes and implantation in women undergoing in vitro fertilization (IVF). The aim of the study was to determine BPA levels in women with polycystic ovary syndrome (PCOS) in comparison to women with tubal factor (TF) infertility who underwent IVF as well as to investigate their effect in critical endp...